Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain

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Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain.

BACKGROUND Little is known about ageing-related changes in the brain that affect emergence from general anaesthesia. We used young adult and aged Fischer 344 rats to test the hypothesis that ageing delays emergence from general anaesthesia by increasing anaesthetic sensitivity in the brain. METHODS Time to emergence was determined for isoflurane (1.5 vol% for 45 min) and propofol (8 mg kg(-1)...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 2015

ISSN: 0007-0912

DOI: 10.1093/bja/aev112